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Suitable studies carried out thus far have not demonstrated geriatric-particular difficulties that might limit the usefulness of oxycodone during the aged.CYP450 3A4 Interaction: The concomitant use with CYP450 3A4 inhibitors (or discontinuation of CYP450 3A4 inducers) may result in a lethal overdose of oxycodone.Neonatal Opioid Withdrawal Syndrome